Bicatalyzed Three-Component Stereoselective Decarboxylative Fluoro-Aldolization for the Construction of Elongated Fluorohydrins - MédiHAL Accéder directement au contenu
Image (Photographie) Année : 2017

Bicatalyzed Three-Component Stereoselective Decarboxylative Fluoro-Aldolization for the Construction of Elongated Fluorohydrins

Résumé

A bicatalyzed three-component cascade between simple aliphatic enolizable aldehydes, a fluorine source, and keto acids has allowed the diastereoselective and enantioselective direct synthesis of carbonyl-elongated vicinal fluorohydrins. The obtained complex acyclic functionalized molecules, possessing up to four stereogenic centers controlled in usually >95% ee, hold great promise for further synthetic developments and rapid incorporation in bioactive elaborated structures.

Dates et versions

medihal-01705716 , version 1 (09-02-2018)

Licence

Domaine public

Identifiants

  • HAL Id : medihal-01705716 , version 1

Citer

Adrien Quintard, Jean Rodriguez. Bicatalyzed Three-Component Stereoselective Decarboxylative Fluoro-Aldolization for the Construction of Elongated Fluorohydrins. Photography. France. 2017. ⟨medihal-01705716⟩
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