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Image (Illustration) Année : 2021

Indirect Tertiary Alcohol Enantiocontrol by Acylative Organocatalytic Kinetic Resolution

Résumé

The stereocontrol of tertiary alcohols represents a recurrent challenge in organic synthesis. In the present paper, we describe a simple, efficient, and indirect method to enantioselectively prepare tertiary alcohols through a chiral isothiourea catalyzed selective acylation of adjacent secondary alcohols. This transformation enables the kinetic resolution (KR) of easily prepared racemic diastereoenriched secondary/tertiary diols providing both monoesters and starting diols in highly enantioenriched forms (s-value >200).

Domaines

Chimie organique

Dates et versions

hal-03255297 , version 1 (09-06-2021)

Licence

Domaine public

Identifiants

  • HAL Id : hal-03255297 , version 1

Citer

Titouan Desrues, Xueyang Liu, Jean-Marc Pons, Valérie Monnier, Jean-Arthur Amalian, et al.. Indirect Tertiary Alcohol Enantiocontrol by Acylative Organocatalytic Kinetic Resolution. Illustration. France. 2021. ⟨hal-03255297⟩
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