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Physical Separation of Enantiomeric Products by Compartmentalized Parallel Kinetic Resolution

Résumé

Accessing each enantiomer of a chiral molecule starting from a racemic mixture remains a daunting challenge in chemistry. Indeed, until now, only a few solutions exist to separate enantiomers of an equimolar mixture of a chiral precursor. In this study, we establish a new strategy to prepare simultaneously and physically separate both enantioenriched enantiomers of a molecule starting from a racemic substrate. This process combines two enantiomeric catalytic systems, working in parallel, and separation by an achiral membrane with selective permeability. This unprecedented system was successfully applied to the simultaneous preparation of both enantiomers of chiral 1,2-diols starting from racemic epoxides using Jacobsen’s hydrolytic kinetic resolution (HKR) in parallel.

Domaines

Chimie organique

Dates et versions

hal-04410546 , version 1 (22-01-2024)

Licence

Paternité

Identifiants

  • HAL Id : hal-04410546 , version 1

Citer

Jingke Hou, Sabine Chevallier-Michaud, Marion Jean, Luc Favre, Damien Hérault, et al.. Physical Separation of Enantiomeric Products by Compartmentalized Parallel Kinetic Resolution. France. 2023. ⟨hal-04410546⟩
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