Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality
Résumé
Atropisomers are fascinating objects of study by themselves for chemists but also find applications in various sub-fields of applied chemistry. Obtaining them in enantiopure form is far from being a solved challenge, and the past decades has seen a surge of methodological developments in that direction. Among these strategies, oxidative aromatization with central-to-axial conversion of chirality has gained increasing popularity. It consists of the oxidation of a cyclic non-aromatic precursors into the corresponding aromatic atropisomers. This review proposes a critical analysis of this research field by delineating it and discussing its historical background and its present state of the art to draw potential future development directions.
Domaines
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Décrit hal-04410491 Article Clément Lemaitre, Stefania Perulli, Ophélie Quinonero, Cyril Bressy, Jean Rodriguez, et al.. Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality. Molecules, 2023, 28, ⟨10.3390/molecules28073142⟩. ⟨hal-04410491⟩
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Cite 10.3390/molecules28073142 Autre Lemaitre, C., Perulli, S., Quinonero, O., Bressy, C., Rodriguez, J., Constantieux, T., García Mancheño, O., & Bugaut, X. (2023). Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality. Molecules, 28(7), 3142. https://doi.org/10.3390/molecules28073142
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Cite hal-04410491 Article Clément Lemaitre, Stefania Perulli, Ophélie Quinonero, Cyril Bressy, Jean Rodriguez, et al.. Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality. Molecules, 2023, 28, ⟨10.3390/molecules28073142⟩. ⟨hal-04410491⟩
